Folate Metabolism Test

What is Folate Metabolism?

Folate metabolism is a complex biochemical process that involves the conversion of folate, a B-vitamin, into its active form. This active form, known as 5-methyltetrahydrofolate (5-MTHF), plays a crucial role in various bodily functions.

The MTHFR gene provides instructions for creating an enzyme called methylenetetrahydrofolate reductase. This enzyme is essential for converting folate into its active form, 5-MTHF.

5-MTHF is vital for several bodily functions, including:

• DNA Synthesis and Repair: It helps in the formation and repair of DNA, the genetic material of cells.
• Neurotransmitter Production: It contributes to the production of neurotransmitters, chemicals that transmit signals between nerve cells.
• Red Blood Cell Formation: It aids in the production of red blood cells, which carry oxygen throughout the body.

When talking about Vitamin B and Folate Metabolism, the question may arise as to what is the difference between Folate and Folic Acid:

• Folate: The natural form of vitamin B9 found in foods like leafy green vegetables, legumes, and fortified grains.
• Folic Acid: The synthetic form of vitamin B9 used in supplements and fortified foods.

Why should you take the Folate Metabolism Test?

A reduced ability to metabolize folate can lead to various health issues, such as:

• Neural Tube Defects: During pregnancy, insufficient folate can increase the risk of neural tube defects in the developing fetus.
• Cardiovascular Disease: Elevated homocysteine levels, a byproduct of impaired folate metabolism, can contribute to heart disease and stroke.
• Other Health Conditions: Poor folate metabolism may also be linked to other health problems, including certain types of cancer and cognitive decline.

Understanding your body’s folate metabolism can help you make informed decisions about your diet and supplement choices to optimize your health.

How the test works?

Understanding the MTHFR Gene

The MTHFR gene provides instructions for creating an enzyme called methylenetetrahydrofolate reductase (MTHFR). This enzyme plays a crucial role in converting folate, a B-vitamin, into its active form, 5-methyltetrahydrofolate (5-MTHF).

The MTHFR C677T variant is a specific genetic mutation that can affect the efficiency of the MTHFR enzyme. Individuals with this variant may have difficulty converting folate into its active form, 5-MTHF.

When the MTHFR enzyme is less efficient, it can lead to:

• Elevated Homocysteine Levels: Homocysteine is an amino acid that, when elevated, can increase the risk of heart disease and stroke.
• Impaired Folate Metabolism: Reduced ability to utilize folate for various bodily functions.

The severity of the MTHFR C677T variant depends on the number of mutated copies of the gene inherited:

• Heterozygous: One mutated copy (inherited from one parent). This can lead to a mild reduction in enzyme activity.
• Homozygous: Two mutated copies (inherited from both parents). This can lead to a significant reduction in enzyme activity, increasing the risk of health problems.

The price of the Folate Metabolism Test is €55.

Test Option: Homocysteine Metabolism (MTHFR-2 Gene)

The Connection Between Folate and Homocysteine

Folate and homocysteine are two important substances in the body that are closely linked. When folate levels are adequate, the body can efficiently convert homocysteine into other substances, such as methionine. However, when folate levels are low, homocysteine can build up in the blood.

Elevated Homocysteine: A Risk Factor

High levels of homocysteine in the blood, a condition known as hyperhomocysteinemia, can increase the risk of various health problems, including:

• Cardiovascular disease
• Stroke
• Dementia

As mentioned before, the MTHFR C677T variant is one of the most well-studied genetic variations that can affect MTHFR enzyme activity.

Another important variant is the MTHFR A1298C variant, also known as MTHFR-2. This variant can also impact folate metabolism and homocysteine levels.

When both the MTHFR C677T and MTHFR A1298C variants are present, the combined effect can be more pronounced. This can lead to a significant reduction in MTHFR enzyme activity and further increase the risk of elevated homocysteine levels.

By understanding the role of the MTHFR gene and its variants, individuals can take steps to optimize their folate intake and reduce their risk of health problems associated with elevated homocysteine levels.

The price of the Homocysteine Metabolism Test is €105.

Sample collection

Only a buccal swab sample is needed for the Folate Metabolism Test, the sample collection kit you will receive will allow you to collect your sample comfortably at home in a simple and safe way. Follow the instructions provided in the kit. You will receive the results of your Folate Metabolism Test in 7-10 working days.